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St. Louis, a large city in Missouri is known as the "Gateway to the West" because it served as a departure point for settlers heading to the west as well as the starting point and the return destination of the Lewis and Clark Expedition. It is a state with both Midwestern and Southern cultural influences, reflecting its history as a border state between the two regions. The state is named after the Missouri Siouan Indian tribe whose Illinois name, ouemessourita (wimihsoorita), (meaning "those who have dugout canoes". The confluence of the Mississippi and Missouri rivers is located in Missouri.

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